In vitro synergistic activity of lidocaine and miconazole against Candida albicans

Maria da Conceição dos Santos Oliveira Cunha, Tarcísio Paulo de Almeida Filho, Francisco Afrânio Cunha, Ana Gesselena da Silva Farias, Ieda Pereira de Souza, Everardo Albuquerque Menezes



Candida albicans is the main yeast isolated from vulvovaginal candidiasis(VVC) and a major antifungal used to treat VVC is miconazole (MZ), it shows local toxic effects, such as irritation and burns. The lidocaine (LD) is a local anesthetic. The aim of this study was to evaluate the synergistic activity of LD/MZ against 19 strains of C. albicans isolated from vaginal secretion. 78.9% of the strains were susceptible to the combination LD/MZ, demonstrating synergism of drugs. These drugs can be used to produce vaginal creams to treat VVC, especially drug resistant.



vulvovaginal candidiasis; antifungal agents; local anesthetic.

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ISSN 1679-9291 (impresso) e ISSN 1807-8648 (on-line) e-mail:


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